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1. MYPI 2015703082 - PYRIDINYL AND FUSED PYRIDINYL TRIAZOLONE DERIVATIVES

Office
Malaysia
Application Number PI 2015703082
Application Date 10.03.2014
Publication Number PI 2015703082
Publication Date 11.09.2014
Publication Kind A
IPC
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventors WANG, HAIXIA
VU, PHONG H.
SMITH, CHRISTOPHER
SCORAH, NICHOLAS
SABAT, MARK
LAWSON, JOHN DAVID
Agents KI WAN SIA
Priority Data 61/776,445 11.03.2013 US
Title
(EN) PYRIDINYL AND FUSED PYRIDINYL TRIAZOLONE DERIVATIVES
Abstract
(EN)
Disclosed are compounds of Formula 1 or pharmaceutically acceptable salts thereof: wherein R 1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.