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1. MYPI 2012700595 - THERAPEUTIC DLL4 BINDING PROTEINS

Office Malaysia
Application Number PI 2012700595
Application Date 28.02.2011
Publication Number PI 2012700595
Publication Date 22.06.2017
Publication Kind A
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/28
C07K 16/00
Applicants AbbVie Inc.
Inventors YINGCHUN LI
JIJIE JAMES GU
SUSAN MORGAN-LAPPE
MINGJIU CHEN
CHUNG-MING HSIEH
Agents PATRICK MIRANDAH
Priority Data 61/309,494 02.03.2010 US
Title
(EN) THERAPEUTIC DLL4 BINDING PROTEINS
Abstract
(EN)
DLL4 BINDING PROTEINS ARE DESCRIBED HEREIN, INCLUDING ANTIBODIES, CDR-GRAFTED ANTIBODIES, HUMANIZED ANTIBODIES, AND DLL4 BINDING FRAGMENTS THEREOF, PROTEINS THAT BIND DLL4 WITH HIGH AFFINITY, AND DLL4 BINDING PROTEINS THAT NEUTRALIZE DLL4 AND/OR VEGF ACTIVITY. THE DLL4 BINDING PROTEINS ARE USEFUL FOR TREATING OR PREVENTING CANCERS AND TUMORS AND ESPECIALLY FOR TREATING OR PREVENTING TUMOR ANGIOGENESIS.