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1. (MYPI 2011002991) 1, 2, 4 -OXADIAZOLE DERIVATIVES AND THEIR THERAPEUTIC USE

Office : Malaysia
Application Number: PI 2011002991 Application Date: 15.12.2009
Publication Number: PI 2011002991 Publication Date: 26.06.2010
Publication Kind : A
Prior PCT appl.: Application Number:PCTEP2009008968 ; Publication Number: Click to see the data
Applicants: ALMIRALL, S.A.
Inventors: GIULIO MATASSA, VICTOR
AGUILAR IZQUIERDO, NURIA
MIR CEPEDA, MARTA
CARRASCAL RIERA, MARTA
FONQUERNA POU, SILVIA
CARDUS FIGUERAS, ARANZAZU
CASTRO PALOMINO LARIA, JULIO CESAR
ERRA SOLA, MONTSERRAT
Agents: TIMOTHY SIAW YEAN HWA
Priority Data: 08382090.2 26.12.2008 EP
Title: (EN) 1, 2, 4 -OXADIAZOLE DERIVATIVES AND THEIR THERAPEUTIC USE
Abstract:
(EN) NEW DERIVATIVES OF GENERAL FORMULA (I), OR PHARMACEUTICALLY ACCEPTABLE SALTS OR N- OXIDES THEREOF WHEREIN, EITHER (I) A IS SELECTED FROM THE GROUP CONSISTING OF -N-, -O- AND -S-; B AND C ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF -N- AND -O-, WITH THE PROVISO THAT TWO OF A, B AND C ARE NITROGEN ATOMS, OR (II) TWO OF A, B AND C ARE -N- AND ONE OF A, B AND C IS -NH-; G IS SELECTED FROM THE GROUP CONSISTING OF-CH2-, -NH- AND-0-; G2 IS SELECTED FROM THE GROUP CONSISTING OF-NR4- AND -0-; R1 REPRESENTS: > A 8 TO 10 MEMBERED BICYCLIC N-CONTAINING HETEROARYL GROUP OPTIONALLY SUBSTITUTED WITH A C1-4 CARBOXYALKYL GROUP OR A C1-4 AMINOALKYL GROUP, > A PYRIDYL GROUP OPTIONALLY SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM HYDROXY GROUPS, C1-4 ALKYL GROUPS, C1-4 CARBOXYALKYL GROUPS, C1-4 HALOALKYL GROUPS, C1-4 ALKOXY GROUPS, AMINO GROUPS, C1-4 AMINOALKYL GROUPS AND C1-4 AMINOALKOXY GROUPS, > A PYRIDONE GROUP SUBSTITUTED WITH ONE OR MORE C1-4 ALKYL GROUPS: C1-4 HALOALKYL GROUPS OR C1-4 AMINOALKYL GROUPS, OR > A GROUP OF FORMULA: WHEREIN: • RA REPRESENTS A HYDROGEN ATOM, A HALOGEN ATOM, A C1-4 ALKYL GROUP, C3-4 CYCLOALKYL GROUP OR A -CF3 GROUP; • RB REPRESENTS A HYDROGEN ATOM, A HALOGEN ATOM, A C1-4 ALKYL GROUP, A -CF3 GROUP OR A C1-4 ALKOXY GROUP; • RD REPRESENTS A HYDROGEN ATOM, A C1-4 ALKYL GROUP OR A C1-4 ALKOXY GROUP; • RC REPRESENTS: O A HYDROGEN ATOM, A C1-4 HYDROXYALKYL GROUP, A C1-4 AMINOALKYL GROUP WHICH IS OPTIONALLY SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM HALOGEN ATOMS, HYDROXY GROUPS AND -CF3 GROUPS; O A 4 TO 6-MEMBERED SATURATED N-CONTAINING HETEROCYCLIC RING OPTIONALLY SUBSTITUTED WITH A C12 CARBOXYALKYL GROUP; O -(CH2)(041C(O)OR’, (CH2)CO4RC(O)NR’ R”, (CH2)CO4RN H C(O)R”, -S(O)2N R’R”, -O-(CH2)(24)N R’ R”, -O-( CH2)(1-4)C(O)O R”, -O-(CH2 )(1-4) C(O)NR’R”, (CH2)CO4RNR’R”, (CH2)(O41CONHS(O)2R’, -(CH2)(04)- NHS(O)2R’ OR —(CH2)(O-NH-(CH2)(L-(NH)(O..I )S(O)2R WHEREIN, • R’ REPRESENTS A HYDROGEN ATOM OR A C14 ALKYL GROUP, •
Also published as:
NZ592798UAa201109217IL213168EP2370431MXMX/a/2011/006505SG172152
JP2012513958US20110311485CN102264731CA2748397EA201100975KR1020110104075
BRPI0918194AU2009331959VN28274ID2012/01220IN4908/DELNP/2011WO/2010/072352