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1. MYPI 20001661 - PYRAZOLOBENZODIAZEPINES.

Office Malaysia
Application Number PI 20001661
Application Date 19.04.2000
Publication Number PI 20001661
Publication Date 21.10.2000
Publication Kind A
IPC
C07D 48/7
C07D 24/3
A61K 31/41
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A61K 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
Applicants F. HOFFMANN-LA ROCHE AG
Inventors QINGJIE DING
JIN-JUN LIU
VINCENT STEWART MADISON
GIACOMO PIZZOLATO
CHUNG-CHEN WEI
PETER MICHAEL WOVKULICH
Agents WONG SAI FONG
Priority Data 60/130,370 21.04.1999 US
Title
(EN) PYRAZOLOBENZODIAZEPINES.
Abstract
(EN)
NOVEL PYRAZOLOBENZODIAZEPINES HAVING THE FORMULA AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, WHEREIN R1, R2, R3 AND R4 ARE AS DEFINED HEREIN INHIBIT CYCLIN-DEPENDENT KINASES (CDKs), IN PARTICULAR CDK2, ARE ANTI-PROLIFERATIVE AGENTS USEFUL IN THE TREATMENT OR CONTROL OF CELL PROLIFERATIVE DISORDERS, IN PARTICULAR BREAST, COLON, LUNG AND PROSTATE TUMORS.