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1. MYPI 20000045 - 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY

Office
Malaysia
Application Number PI 20000045
Application Date 06.01.2000
Publication Number PI 20000045
Publication Date 29.03.2012
Publication Kind A
IPC
A61K 31/536
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
536ortho- or peri-condensed with carbocyclic ring systems
C07D 265/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
041,3-Oxazines; Hydrogenated 1,3-oxazines
12condensed with carbocyclic rings or ring systems
14condensed with one six-membered ring
24with hetero atoms directly attached in positions 2 and 4
Applicants NORGINE BV
Inventors PALMER, RICHARD MICHAEL JOHN
MITCHELL, TIMOTHY JOHN
DOWNHAM, ROBERT
CARR, BEVERLEY JANE
HODSON, HAROLD FRANCIS
DUNK, CHRISTOPHER ROBERT
Agents MICHAEL SOO CHOW MING
Priority Data 9900416.0 08.01.1999 GB
Title
(EN) 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY
Abstract
(EN) THE USE OF A COMPOUND COMPRISING FORMULA (?):OR A SALT, ESTER,AMIDE OR PRODRUG THEROF IN THE INHIBITION OF AN ENZYME WHOSE PREFERRED MODE OF ACTION IS TO CATALYSE THE HYDROLYSIS OF AN ESTER FUNCTIONALITY, E.G. IN THE CONTROL AND INHIBITION OF UNWANTED ENZYMES IN PRODUCTS AND PROCESSES. THE COMPOUNDS ARE ALSO USEFUL IN MEDICINE E.G. IN THE TREATMENT OF OBESITY AND RELATED CONDITIONS. THE INVENTION ALSO RELATES TO NOVEL COMPOUNDS WITHIN FORMULA (?), TO PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. IN FORMULA (?) A IS A 6-MEMBERED AROMATIC OR HETEROAROMATIC RING; AND R1 IS A BRANCHED OR UNBRANCHED ALKYL (OPTIONALLY INTERRUPTED BY ONE OR MORE OXYGEN ATOMS), ALKENYL, ALKYNYL, CYCLOALKYL, CYCLOALKENYL, ARYL, ARYLALKYL, REDUCED ARYLALKYL, ARYLALKENYL, HETEROARYL, HETERORYLALKYL, HETEROARYLALKENYL, REDUCED ARYL, REDUCED HETEROARYL, REDUCED HETEROARYLALKYL OR A SUBSTITUTED DRIVATIVE OF ANY OF THE FOREGOING GROUPS.
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