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1. MXPA/a/2001/002542 - NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE

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Office Mexico
Application Number PA/a/2001/002542
Application Date 09.03.2001
Publication Number PA/a/2001/002542
Publication Date 17.02.2003
Publication Kind A
IPC
A61K 31/675
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07F 9/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
553having one nitrogen atom as the only ring hetero atom
576Six-membered rings
58Pyridine rings
C07F 9/6509
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645having two nitrogen atoms as the only ring hetero atoms
6509Six-membered rings
C07F 9/6512
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645having two nitrogen atoms as the only ring hetero atoms
6509Six-membered rings
6512having the nitrogen atoms in positions 1 and 3
C07F 9/653
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6527having nitrogen and oxygen atoms as the only ring hetero atoms
653Five-membered rings
Applicants METABASIS THERAPEUTICS, INC.
Inventors DANG, Qun
KASIBHATLA, Srinivas, Rao
REDDY, K., Raja
ERION, Mark, D.
REDDY, M., Rami
AGARWAL, Atul
Agents JAVIER UHTHOFF ORIVE.*
Priority Data 09111077 07.07.1998 US
09135504 22.06.1998 US
Title
(EN) NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE
(ES) NUEVOS INHIBIDORES HETEROAROMATICOS DE FRUCTOSA-1,6-BIFOSFATASA
Abstract
(EN)
Novel FBPase inhibitors of formula (I) and (X) are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.

(ES)
La presente invención se refiere a nuevos inhibidores FBPasa de fórmula (I) y (X) empleados en el tratamiento de la diabetes y otras condiciones asociadas con niveles elevados de glucosa en la sangre.
Also published as
AU2000010905
AU2003242500
BRPI9913532
CA2343027
CN101125864
CN1326459
CN1704423
CN1900087
CZ297264
CZPV2006-471
DE000069910045
DK1112275
EP1018742
EP1112275
ES2204170
IL141772
IL170472
ININ/PCT/2001/262/KOL
JP2002524463
KR1020010085776
KR1020070053264
NO20011174
NZ510308
PLP.346520
PT1112275
RU02327700
SK20010316
US6779196
WO/2000/014095
ZA2001/01711
ZA200101711
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