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1. MXPA/a/2000/012525 - NOVEL THIOLESTERS AND USESTHEREOF

Office Mexico
Application Number PA/a/2000/012525
Application Date 15.12.2000
Publication Number PA/a/2000/012525
Publication Date 31.07.2001
Publication Kind A
IPC
A61K 39/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
C07C 319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
319Preparation of thiols, sulfides, hydropolysulfides or polysulfides
C07C 327/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
32having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C07D 213/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
16containing only one pyridine ring
20Quaternary compounds thereof
C12N 7/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
06by chemical treatment
Applicants THE GOVERNMENT OF THE UNITED STATES OF AMERICA represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors TURPIN, Jim, A.
SONG, Yongsheng
INMAN, John, K.
HUANG, Mingjun
WALLQVIST, Anders
MAYNARD, Andrew
COVELL, David, G.
RICE, William, G.
Agents MIGUEL A. ESTEVA*
Priority Data 60/089,842 19.06.1998 US
Title
(EN) NOVEL THIOLESTERS AND USESTHEREOF
(ES) NUEVOS TIOLESTERES Y USOS DE LOS MISMOS
Abstract
(EN)
This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.

(ES)
La invención pertenece al descubrimiento de una nueva familia de tiolésteres y el uso de los mismos. Tambien se proporcionan compuestos viricidas y formulaciones farmacéuticas que comprenden estos nuevos tiolésteres. La invención también proporciona virus inactivados por tiolésteres y proteínas virales que forman complejos con tiolésteres.