(EN) The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted-(CH2)h-het, R2 is substituted and unsubstituted C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted-(CH2)h-C3-8 cycloakyl, substituted and unsubstituted -(CH2)h-C3-8 cycloalkenyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH2)h-heterocyclic ring, substituted and unsubstituted -(CH2)i-X-R4 (X is -O-, -S(=O)j-, -NR7-, -S(=O)2NR8-, or -C(=O)-), and -(CH2)iCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
(ES) La presente invención proporciona un compuesto de la fórmula (1). O sales farmacéuticamente aceptables del mismo en donde R1 es C4-12 alquilo, C4-12 alquenilo, C4-12 alquinilo, -(CH2)h- C3-8 cicloalquilo, -(CH2)h-arilo substituido y no substituido,-(CH2)h-het substituido y no sustituido, R2 es -C1-12 alquilo substituido y no substituido, C2-12 alquilo substituido y no substituido, C2-12 alquenilo substituido y no substituido, C2-12 alquinilo substituido y no substituido, -(CH2)h-C3-8 cicloalquilo substituido y no substituido, - (CH2)h- C3-8 cicloalquenilo substituido y no substituido, -(CH2)h-arilo sustituido y no sustituido, - (CH2)h-anillo heterocíclico substituido y no substituido -(CH2)i-X-R4- (X es -O-, -S(=O)j- substituido y no substituido, -NR7-, -S(=O)2NR8-, o -C(=O)-), y -(CH2)iCHR5R6. los compuestos son inhibidores de metaloproteinasa matriz involucradas en la degradación de tejido.
