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1. MXPA/a/2000/000557 - PROCESS FOR PREPARING AMINOARYLACETYLENES

Office
Mexico
Application Number PA/a/2000/000557
Application Date 14.01.2000
Publication Number PA/a/2000/000557
Publication Date 26.06.2001
Publication Kind A
IPC
C07C 000/00000
Applicants CATALYTICA PHARMACEUTICALS, INC.
Inventors JOHN M. GRUBER
Agents JAVIER UHTHOFF-ORIVE
Priority Data 08892278 14.07.1997 US
Title
(EN) PROCESS FOR PREPARING AMINOARYLACETYLENES
(ES) PROCESO PARA PREPARAR AMINOARILCETILENOS
Abstract
(EN) This invention provides a process for preparing aminoarylacetylenes comprising reacting an N-arylmethylidene aminoarylhalide with a terminal acetylene in the presence of a base and a catalyst system comprising a palladium catalyst and a cuprous salt to produce a novel N-arylmethylidene aminoarylacetylene, and hydrolyzing the N-arylmethylidene aminoarylacetylene to the aminoarylacetylene. In one embodiment, the invention provides a process for preparing aminophenylacetylenes comprising reacting an N-benzylidene aminophenylhalide with a terminal acetylene in the presence of a base and the catalyst system to produce a novel N-benzylidene aminophenylacetylene, and hydrolyzing the N-benzylidene aminophenylacetylene to the aminophenylacetylene.
(ES) La presente invención proporciona un proceso para la preparación de aminoarilacetilenos, que comprende hacer reaccionar un aminoarilhaluro de N-arilmetilideno con un acetileno terminal, en presencia de una base y un sistema catalizador que comprende un catalizador de paladio y una sal cuprosa, para producir un nuevo aminoarilacetileno de N-arilmetilideno, e hidrolizar el aminoarilacetilideno de N-arilmetilideno para obtener el aminoarilacetilideno. En una modalidad, la presente invención proporciona un proceso para la preparación de aminofenilacetilenos que comprende hacer reaccionar un aminofenilhaluro de N-bencilideno con un acetileno terminal, en presencia de una base y el sistema catalizador, para producir un nuevo aminofenilacetileno de N-bencilideno, e hidrolizar el aminofenilacetileno de N-bencilideno para obtener el aminofenilacetileno.
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