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1. MXMX/a/2008/016273 - KV1.5 POTASSIUM CHANNEL INHIBITORS

Office Mexico
Application Number MX/a/2008/016273
Application Date 17.12.2008
Publication Number MX/a/2008/016273
Publication Date 12.05.2009
Publication Kind A
IPC
A61K 31/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A61P 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
C07D 471/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
Applicants WYETH.*
Inventors JOHN MICHAEL JANUSZ
SHENGDE WU
NEIL T. FAIRWEATHER
WENLIN LEE
BENJAMIN E. BLASS
ANDREW J. FLUXE
STEPHEN J. HODSON
JAMES M. RIDGEWAY, II
Agents OCTAVIO SALDAÑA VILLANUEVA.*
Priority Data 60/815,066 20.06.2006 US
Title
(EN) KV1.5 POTASSIUM CHANNEL INHIBITORS
(ES) INHIBIDORES DE CANAL DE POTASIO KV1.5
Abstract
(EN)
The present invention relates to 4-oxo-1,3,8-triaza-spiro[4.5]decanes which are useful as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic activity. The present invention further relates to compositions and methods for treating atrial-selective antiarrhythmia.

(ES)
La presente invención se relaciona con 4-oxo-1,3,8-triaza-espiro[4.5]decanos que sonútiles como inhibidores de canal de potasio Kv1.5 que proporcionan actividad antiarrítmica selectiva auricular. La presente invención se relaciona adicionalmente con composiciones y métodos para tratar antiarritmia selectiva auricular.

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