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1. MXMX/a/2007/010833 - USE OF OPIOID ANTAGONISTS TO ATTENUATE ENDOTHELIAL CELL PROLIFERATION AND MIGRATION

Office Mexico
Application Number MX/a/2007/010833
Application Date 05.09.2007
Publication Number MX/a/2007/010833
Publication Date 13.05.2009
Publication Kind A
IPC
A61K 31/439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
439the ring forming part of a bridged ring system, e.g. quinuclidine
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants THE UNIVERSITY OF CHICAGO
Inventors JONATHAN MOSS
MARK LINGEN
PATRICK A. SINGLETON
JOE G. N. GARCIA
Agents JOSE F. HINOJOSA CUELLAR.*
Priority Data 60/659,193 07.03.2005 US
60/725,703 12.10.2005 US
60/731,009 28.10.2005 US
60/760,851 20.01.2006 US
Title
(EN) USE OF OPIOID ANTAGONISTS TO ATTENUATE ENDOTHELIAL CELL PROLIFERATION AND MIGRATION
(ES) USO DE ANTAGONISTAS OPIOIDES PARA ATENUAR PROLIFERACION Y MIGRACION DE CÉLULAS ENDOTELIALES
Abstract
(EN)
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.

(ES)
La invención provee métodos para atenuar, v.gr., inhibir o reducir, proliferación y migración celular, particularmente proliferación y migración celular endotelial, incluyendo las asociadas con angiogénesis, usando antagonistas opioides, incluyendo, pero no limitado a, aquellos que son antagonistas periféricamente restringidos.