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1. MXMX/a/2011/005677 - ANTI-cMET ANTIBODY

Office
Mexico
Application Number MX/a/2011/005677
Application Date 30.05.2011
Publication Number MX/a/2011/005677
Publication Date 28.07.2011
Publication Kind A
IPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Applicants PIERRE FABRE MEDICAMENT.*
Inventors Liliane Goetsch
Cédric Bes
Thierry Wurch
Agents MARIANO SONI.*
Priority Data PCT/IB2008/055663 02.12.2008 IB
61/184,502 05.06.2009 US
Title
(EN) ANTI-cMET ANTIBODY
(ES) ANTICUERPO ANTI-CMET NOVEDOSO
Abstract
(EN) Antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity, said antibody comprising a modified hinge region. A composition comprising such an antibody antagonist to c-Met and its use as a medicament for treating cancer.
(ES) La invención se refiere a un anticuerpo novedoso capaz de unirse específicamente al receptor c-Met humano y/o capaz de inhibir específicamente la actividad de tirosina quinasa de dicho receptor, con una actividad antagonista mejorada, comprendiendo dicho anticuerpo una región bisagra modificada. La invención se refiere además a una composición que comprende ese tipo de anticuerpo antagonista de c-Met y su uso como un medicamento para tratar el cáncer.
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