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1. MXMX/a/2010/000533 - MULTIPLEXED ANALYSES OF TEST SAMPLES

Office
Mexico
Application Number MX/a/2010/000533
Application Date 13.01.2010
Publication Number MX/a/2010/000533
Publication Date 15.06.2010
Publication Kind A
IPC
C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Applicants SOMALOGIC, INC.
Inventors LARRY GOLD.
DOMINIC ZICHI
DANIEL J. SCHNEIDER
BRUCE EATON
DAN NIEUWLANDT
MARTY STANTON
SHASHI GUPTA
STEPHAN KRAEMER
Agents FRANCISCO JAVIER UHTHOFF ORIVE.*
Priority Data 60/950,281 17.07.2007 US
60/950,283 17.07.2007 US
60/950,293 17.07.2007 US
61/031,420 26.02.2008 US
61/051,594 08.05.2008 US
Title
(EN) MULTIPLEXED ANALYSES OF TEST SAMPLES
(ES) ANALISIS MULTIPLEXADOS DE MUESTRAS DE PRUEBAS
Abstract
(EN)
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of anon-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

(ES)
La presente invención describe métodos, dispositivos, reactivos y kits para la detección de una o más moléculas objetivo que pudieran estar presentes en una muestra de prueba. Los métodos, dispositivos, kits y reactivos descritos facilitan la detección y cuantificación de un objetivo que no esácido nucleico (por ejemplo, un objetivo de proteína) en una muestra de prueba al detectar y cuantificar unácido nucleico (es decir, un aptámero). Los métodos descritos crean un sustituto deácido nucleico para un objetivo que no esácido nucleico, permitiendo asíque la amplia variedad de tecnologías deácido nucleico, incluyendo amplificación, sean aplicadas a una gama más amplia de objetivos deseados, especialmente objetivos de proteínas. La invención describe además construcciones de aptámeros que facilitan el uso de aptámeros en una variedad de aplicaciones de detección analítica.