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1. MXMX/a/2010/000499 - PREPARATION OF N-ALKYLATED OPIATES BY REDUCTIVE AMINATION

Office
Mexico
Application Number MX/a/2010/000499
Application Date 12.01.2010
Publication Number MX/a/2010/000499
Publication Date 23.04.2010
Publication Kind A
IPC
C07D 489/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
489Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro furan ring systems, e.g. derivatives of -morphinan of the formula:
02with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
C07D 489/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
489Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro furan ring systems, e.g. derivatives of -morphinan of the formula:
06with a hetero atom directly attached in position 14
08Oxygen atom
Applicants MALLINCKRODT INC.*
Inventors GARY L. CANTRELL
CHRISTOPHER W. GROTE
TAO JIANG
BRIAN ORR
Agents FRANCISCO JAVIER UHTHOFF ORIVE.*
Priority Data 60/950,127 17.07.2007 US
Title
(EN) PREPARATION OF N-ALKYLATED OPIATES BY REDUCTIVE AMINATION
(ES) PREPARACION DE OPIACEOS N-ALQUILADOS POR AMINACION REDUCTIVA
Abstract
(EN)
The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.

(ES)
La presente invención se centra en la reducción de una porción N-imina o una porción hemiaminal de un morfinano en presencia de un catalizador asimétrico de rutenio, rodio o iridio y una fuente de hidrógeno.