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1. MX2019007963 - EXPANSION DE LINFOCITOS INFILTRANTES DE TUMOR (TIL) CON AGONISTAS DE LA SUPERFAMILIA DE RECPTOR DE FACTOR DE NECROSIS TUMORAL (TNFRSF) Y COMBINACIONES TERAPEUTICAS DE TIL- Y AGONISTAS DE TNFRSF.

Office
Mexico
Application Number 2019007963
Application Date 01.07.2019
Publication Number 2019007963
Publication Date 21.10.2019
Publication Kind A
IPC
C12N 5/0783
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
CPC
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 5/0634
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0634Cells from the blood or the immune system
C12N 5/0636
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0634Cells from the blood or the immune system
0636T lymphocytes
C12N 2501/2302
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
23Interleukins [IL]
2302Interleukin-2 (IL-2)
C12N 2501/25
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
20Cytokines; Chemokines
25Tumour necrosing factors [TNF]
Applicants IOVANCE BIOTHERAPEUTICS, INC.
Inventors Michael T. LOTZE
Krit RITTHIPICHAI
Priority Data 62/443,556 06.01.2017 US
62/460,477 06.01.2017 US
62/532,807 06.01.2017 US
62/567,151 06.01.2017 US
Title
(EN) EXPANSION DE LINFOCITOS INFILTRANTES DE TUMOR (TIL) CON AGONISTAS DE LA SUPERFAMILIA DE RECPTOR DE FACTOR DE NECROSIS TUMORAL (TNFRSF) Y COMBINACIONES TERAPEUTICAS DE TIL- Y AGONISTAS DE TNFRSF.
(ES) EXPANSION DE LINFOCITOS INFILTRANTES DE TUMOR (TIL) CON AGONISTAS DE LA SUPERFAMILIA DE RECPTOR DE FACTOR DE NECROSIS TUMORAL (TNFRSF) Y COMBINACIONES TERAPEUTICAS DE TIL- Y AGONISTAS DE TNFRSF.
Abstract
(EN)
Methods of expanding tumor infiltrating lymphocytes (TILs) using a tumor necrosis factor receptor superfamily (TNFRSF) agonist, such as a 4- IBB agonist, a CD27 agonist, a glucocorticoid-induced TNF receptor-related agonist, an OX40 agonist, a HVEM agonist, or a CD95 agonist, and uses of such expanded TILs in the treatment of diseases such as cancer are disclosed herein. In addition, in some embodiments, therapeutic combinations of TILs and TNFRSF agonists useful in the treatment of diseases such as cancer, including compositions, uses, and dosing regimens thereof, are disclosed herein.

(ES)
En la presente se describen métodos para expandir linfocitos infiltrantes de tumor (TIL) usando un agonista de la superfamilia del receptor de factor de necrosis tumoral (TNFRSF), como por ejemplo un agonista 4-IBB, un agonista CD27, un agonista relacionado con el receptor TNF inducido por glucocorticoide, un agonista OX40, un agonista HVEM o un agonista CD95, y usos de estos TIL expandidos en el tratamiento de enfermedades como por ejemplo cáncer. Además, en algunas modalidades se describen en la presente combinaciones terapéuticas de los TIL y agonistas de TNFRSF útiles en el tratamiento de enfermedades como por ejemplo cáncer, que incluye composiciones, usos y regímenes de dosificación de los mismos.