Processing

Please wait...

Settings

Settings

Goto Application

1. MX2018012619 - DERIVADOS DE BISFENOL Y SU USO COMO MODULADORES DE LA ACTIVIDAD DEL RECEPTOR DE ANDROGENO.

Office Mexico
Application Number 2018012619
Application Date 15.10.2018
Publication Number 2018012619
Publication Date 24.06.2019
Publication Kind A
IPC
A61K 31/09
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
085having an ether linkage to aromatic ring nuclear carbon
09having two or more such linkages
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
A61P 17/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
Applicants BRITISH COLUMBIA CANCER AGENCY BRANCH
Inventors Marianne Dorothy SADAR
Jun WANG
Raymond ANDERSEN
Carmen Adriana BANUELOS
Yu- Chi YANG
Kunzhong JIAN
Nasrin R. MAWIL
Priority Data 62/323,196 15.04.2016 US
Title
(EN) DERIVADOS DE BISFENOL Y SU USO COMO MODULADORES DE LA ACTIVIDAD DEL RECEPTOR DE ANDROGENO.
(ES) DERIVADOS DE BISFENOL Y SU USO COMO MODULADORES DE LA ACTIVIDAD DEL RECEPTOR DE ANDROGENO.
Abstract
(EN)
Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

(ES)
Se proporcionan los compuestos que tienen una estructura de la Fórmula I: (ver Fórmula) o una sal, tautómero o estereoisómero farmacéuticamente aceptable de estos, donde R1, R2, R3, R11a, R11b, R11c, R11d, y X, son tal como se definen en la. También se proporcionan usos de tales compuestos para modular la actividad del receptor de andrógeno, diagnósticos por imaginología de cáncer y terapéutica, y métodos para el tratamiento de sujetos que lo necesitan, que incluye el cáncer de próstata.