Processing

Please wait...

Settings

Settings

Goto Application

1. MX2016012691 - NUEVOS COMPUESTOS DE SUCCINATO PERMEABLES A LA CELULA.

Office
Mexico
Application Number 2016012691
Application Date 28.09.2016
Publication Number 2016012691
Publication Date 16.12.2016
Publication Kind A
IPC
C07D 281/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
18Eight-membered rings
CPC
A61K 8/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
46containing sulfur
A61K 8/4926
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4906with one nitrogen as the only hetero atom
4926having six membered rings
A61K 8/498
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4973with oxygen as the only hetero atom
498having 6-membered rings or their condensed derivatives, e.g. coumarin
A61Q 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
C07C 327/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
28having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07C 327/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
30having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Applicants NEUROVIVE PHARMACEUTICAL AB
Inventors Eskil ELMER
Magnus Joakim HANSSON
Karl Henrik Johannes EHINGER
Steven MOSS
Priority Data PA 2014 70190 08.04.2014 DK
Title
(ES) NUEVOS COMPUESTOS DE SUCCINATO PERMEABLES A LA CELULA.
Abstract
(EN) The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.