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1. MXMX/a/2007/011562 - A PROCESS FOR THE PREPARATION OF 6-O-METHYL ERYTHROMYCIN A DERIVATIVE

Office Mexico
Application Number MX/a/2007/011562
Application Date 20.09.2007
Publication Number MX/a/2007/011562
Publication Date 27.06.2008
Publication Kind A
IPC
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Applicants IND-SWIFT LABORATORIES LIMITED
Inventors Srinivasan, Chidambaram, Venkateswaran
Saxena, Rahul
Gupta, Pranav
Agents ROGELIO VALDÉS PILA
Title
(EN) A PROCESS FOR THE PREPARATION OF 6-O-METHYL ERYTHROMYCIN A DERIVATIVE
(ES) UN PROCESO PARA LA PREPARACIÓN DE DERIVADOS DE LA 6-0-METIL ERITROMICINA A
Abstract
(EN)
The present invention relates to an improved process for the preparation of 6-O-methylerythromycin A derivatives, intermediates of clarithromycin, by selective methylation of erythromycin A derivative in a mixture of a acyclic or cyclic alkanes having C6-C10carbon atoms, and a polar aprotic solvent using a methylating agent in the presence of a base under mild conditions.

(ES)
La presente invención se relaciona con un proceso mejorado para la preparación de derivados de la 6-O-metil eritromicina A, intermediarios de la claritromicina, mediante la metilación selectiva del derivado de la eritromicina A en una mezcla de alcanos acíclicos o cíclicos que tienen C6-C10átomos de carbono, tales como hexanos, heptanos, ciclohexano y un solvente polar aprótico usando un agente de metilación en presencia de una base bajo condiciones moderadas.

Also published as
EP6728411
ESP200750057