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1. MXMX/a/2007/010672 - HUMANIZED L243 ANTIBODIES

Office Mexico
Application Number MX/a/2007/010672
Application Date 31.08.2007
Publication Number MX/a/2007/010672
Publication Date 02.09.2008
Publication Kind A
IPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C12N 15/13
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
Applicants IMMUNOMEDICS, INC.
Inventors David M. Goldenberg
Hans J. Hansen
Zhengxing Qu
Chien-Hsing Chang
Agents CESAR RAMOS DE MIGUEL*
Priority Data 60/657,695 03.03.2005 US
Title
(EN) HUMANIZED L243 ANTIBODIES
(ES) ANTICUERPOS L243 HUMANIZADOS
Abstract
(EN)
Humanized antibodies are provided that specifically bind HLA-DR. The antibodies recognize the epitope recognized by the murine monoclonal antibody L243. Processes for preparing such antibodies, pharmaceutical compositions containing such antibodies, and clinical therapuetic and diagnostic, as well as research-related uses for such antibodies, are provided.

(ES)
Se proporcionan anticuerpos humanizados que enlazan en forma específica HLA-DR. Los anticuerpos reconocen el epítope reconocido por el anticuerpo monoclonal de múrido L243. Se proporcionan procesos para preparar dichos anticuerpos, composiciones farmacéuticas que contienen dichos anticuerpos, y usos terapéuticos y de diagnóstico clínicos de dichos anticuerpos, asícomo usos de dichos anticuerpos relacionados con la investigación.

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