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1. (MXMX/a/2007/005189) QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS

Office : Mexico
Application Number: MX/a/2007/005189 Application Date: 30.04.2007
Publication Number: MX/a/2007/005189 Publication Date: 22.01.2008
Publication Kind : A
Prior PCT appl.: Application Number:EP2005011662 ; Publication Number:06048225 Click to see the data
IPC:
A61K 31/439
A61P 29/00
C07D 453/02
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
439
the ring forming part of a bridged ring system, e.g. quinuclidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
Applicants: NOVARTIS AG.*
Inventors: Neil John Press
Simon James Watson
Stephen Paul Collingwood
Brian Cox
Urs Baettig
Sudhakar Devidasrao Garad
Hyungchul Kim
Dimitris Papoutsakis
Agents: CESAR RAMOS DE MIGUEL*
Priority Data: 0424284.8 02.11.2004 GB
Title: (EN) QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS
(ES) DERIVADOS DE QUINUCLIDINA Y SU USO COMO ANTAGONISTAS DEL RECEPTOR MUSCARINICO M3
Abstract:
(EN) Compounds of Formula (I);in salt or zwitterionic form wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
(ES) Los compuestos de la fórmula I;en forma de sal o ión anfotérico, en donde R1, R2, R3, y R4 tienen los significados indicados en la memoria descriptiva, sonútiles para el tratamiento de condiciones que sean mediadas por el receptor muscarínico M3, en especial enfermedades inflamatorias u obstructivas de las vías respiratorias. También se describen composiciones farmacéuticas que contienen los compuestos, y un proceso para la preparación de los compuestos.
Also published as:
NO20072371KR1020070073849IL182695AR054090MA29080BRPI0517945
PE2006-0609EP2206499EP1811999ZA2007/02772JP2008518890RU02399620
ES2353142US20090048281US20100168132CN101056634CA2583237PT1811999
TN2007000164NZ554302AU2005300710DK1811999ID047.2601MYPI 20054966
IN2750/DELNP/2007WO/2006/048225