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1. MX365313 - COMPOSICIÓN FARMACÉUTICA ORAL QUE COMPRENDE A,A,A-TRIFLUOROTIMIDIN A Y CLORHIDRATO DE 5-CLORO-6-(2-IMINOPIRROLIDINA-1-IL)METIL-2,4(1H ,3H)-PIRIMIDINA DIONA.

Office
Mexico
Application Number 2014009834
Application Date 14.08.2014
Publication Number 365313
Publication Date 11.09.2014
Grant Number 365313
Grant Date 29.05.2019
Publication Kind B
IPC
A61K 31/513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
CPC
A61K 31/513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
A61K 9/2059
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
A61K 9/0053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
A61K 31/7072
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
7072having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
Applicants TAIHO PHARMACEUTICAL CO., LTD.
Inventors OHNISHI, Yoshito
OGATA, Tetsuo
Priority Data 2012-031144 15.02.2012 JP
Title
(EN) COMPOSICIÓN FARMACÉUTICA ORAL QUE COMPRENDE A,A,A-TRIFLUOROTIMIDIN A Y CLORHIDRATO DE 5-CLORO-6-(2-IMINOPIRROLIDINA-1-IL)METIL-2,4(1H ,3H)-PIRIMIDINA DIONA.
(ES) COMPOSICIÓN FARMACÉUTICA ORAL QUE COMPRENDE A,A,A-TRIFLUOROTIMIDIN A Y CLORHIDRATO DE 5-CLORO-6-(2-IMINOPIRROLIDINA-1-IL)METIL-2,4(1H ,3H)-PIRIMIDINA DIONA.
Abstract
(EN) Provided is an FTD- and TPI-containing oral pharmaceutical composition which can be orally administered and is stable even under high humidity conditions. This oral pharmaceutical composition contains a,a,a-trifluorothymidine and 5-chloro-6-(2-iminopyrrolidine-1-yl) methyl-2,4 (1H, 3H)-pyrimidine dione hydrochloride as the active ingredient, and contains substantially no additives comprising metal salts.
(ES) La invención presente proporciona una composición farmacéutica oral que contiene FTD y TPI que puede ser administrada oralmente y que es estable incluso bajo condiciones de alta humedad; una composición farmacéutica oral que comprende a,a,a-trifluorotimidin a y clorhidrato de 5-cloro-6-(2-iminopirrolidina-1-il) metil-2,4(1H,3H)-pirimidina diona como un ingrediente activo; y que está sustancialmente libre de un aditivo que comprende una sal metálica.