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1. (MX2012008553) COMPUESTOS DE AMIDA INVERSA COMO INHIBIDORES DE PROTEINA DESACETILASA Y METODOS DE USO DE LOS MISMOS.

Office : Mexico
Application Number: 2012008553 Application Date: 23.07.2012
Publication Number: 2012008553 Publication Date: 30.11.2012
Publication Kind : A
IPC:
C07D 239/42
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
42
One nitrogen atom
Applicants: ACETYLON PHARMACEUTICALS, INC.*ACETYLON PHARMACEUTICALS, INC.*
Inventors: JOHN H. VAN DUZER
DEJIAN XIE
JAMES ELLIOT BRADNER
RALPH MAZITSCHEK
WALTER OGIER
GUOXIANG HUANG
NAN YU
Priority Data: 61/336,460 22.01.2010 US
Title: (ES) COMPUESTOS DE AMIDA INVERSA COMO INHIBIDORES DE PROTEINA DESACETILASA Y METODOS DE USO DE LOS MISMOS.
Abstract:
(EN) The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
Also published as:
RSP-2016/0849EP2526093IL221056JP2013518050SG182646CA2787756
EA201290677CL2012002026SG10201500444TKR1020120118480CN102933558IL242867
BR112012018246CN105727298CN105753739JP2016153425NZ601655EP3091004
AU2011207289DK2526093ES2592278AU2016213729ID2013/01525PH1/2012/501492
TH151341IN1913/KOLNP/2012PT2526093WO/2011/091213