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1. (MX2011006232) DIHIDROPIRIDONA AMIDAS COMO MODULADORES DE P2X7.

Office : Mexico
Application Number: 2011006232 Application Date: 10.06.2011
Publication Number: 2011006232 Publication Date: 24.06.2011
Publication Kind : A
IPC:
C07D 401/12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
CPC:
C07D 401/12
C07D 413/12
Applicants: F. HOFFMANN-LA ROCHE AG.*F. HOFFMANN-LA ROCHE AG.*
Inventors: JACOB BERGER
KEITH ADRIAN MURRAY WALKER
SHU-HAI ZHAO
JOAN MARIE CAROON
NANCY ELISABETH KRAUSS
FRANCISCO JAVIER LOPEZ-TAPIA
Priority Data: 61/203,482 23.12.2008 US
Title: (ES) DIHIDROPIRIDONA AMIDAS COMO MODULADORES DE P2X7.
Abstract:
(EN) Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
Also published as:
AR074843IL213417MXMX/a/2011/006232SG172336EP2385939JP2012513433
CN102264723CA2745864KR1020110086768AU2009331659IN4420/CHENP/2011WO/2010/072597