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1. MXPA/a/2003/001877 - 2-GUANIDINO-4-ARYL-QUINAZOLINE

Office
Mexico
Application Number PA/a/2003/001877
Application Date 03.03.2003
Publication Number PA/a/2003/001877
Publication Date 17.11.2003
Publication Kind A
IPC
A61K 31/517
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07D 239/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
78with hetero atoms directly attached in position 2
84Nitrogen atoms
Applicants MERCK PATENT GESELLSCHAFT HAFTUNG
Inventors WILM, Claudia
GERICKE, Rolf
BEIER, Norbert
Agents JAVIER UHTHOFF ORIVE
Priority Data 10043667 05.09.2000 DE
Title
(EN) 2-GUANIDINO-4-ARYL-QUINAZOLINE
(ES) 2-GUANIDIN-4-ARILQUINAZOLINAS
Abstract
(EN)
The invention relates to compounds of formula (I), wherein Y represents (II) or (III) and Ar, R1, R2, R5, R6, R7 and R8 have the above-mentioned meaning, in addition to the salts and solvates thereof and the use thereof as NHE-3-inhibitors.

(ES)
La presente invención describe compuestos de fórmula I (ver fórmula) donde Y es y Ar R1, R2, R5, R6, R7 y R8 tienen los valores que se definen, y las sales y los solvatos de los mismos, y su uso como inhibidores de NHE-3.