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1. KR1020060039286 - ORALLY ADMINISTRABLE ANTI-MALARIAL COMBINED PREPARATION AND PREPARATION PROCESS THEREOF FOR IMPROVING DRUG STABILITY AND MEDICINE EFFECT

Office
Republic of Korea
Application Number 1020040088413
Application Date 02.11.2004
Publication Number 1020060039286
Publication Date 08.05.2006
Grant Number 1006233220000
Grant Date 19.09.2006
Publication Kind B1
IPC
A61K 31/357
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
357having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
Applicants SHIN POONG PHARMACEUTICAL CO., LTD.
신풍제약주식회사
Inventors LEE, SUNG TAE
이성태
PARK, WOO YLE
박우일
NOH, JEONG RYUL
노정열
JEONG, HYEON GUN
정현근
LEE, CHUL KYU
이철규
CHUN, SUNG HYUN
전성현
JUNG, HYUN KYU
정현규
Agents 최규팔
이은선
Title
(EN) ORALLY ADMINISTRABLE ANTI-MALARIAL COMBINED PREPARATION AND PREPARATION PROCESS THEREOF FOR IMPROVING DRUG STABILITY AND MEDICINE EFFECT
(KO) 경구투여용 항말라리아 배합 제제 및 그의 제조방법
Abstract
(EN)

PURPOSE: An orally administrable anti-malarial combined preparation and a preparation process thereof are provided to improve drug stability of the preparation, improve medicine effect of drugs, and inhibit proliferation of drug-resistant bacteria causing malaria.

CONSTITUTION: The orally administrable anti-malarial combined preparation comprises artemisinine or its derivatives and pyronaridine or its salt, and a pharmaceutically acceptable carrier, wherein the weight ratio of the artemisinine or its derivatives, and pyronaridine or its salt is 1:1 to 1:6. The pharmaceutically acceptable carrier is polyethylene glycol, hydroxypropyl methylcellulose, methylcellulose or ethylcellulose, and the preparation has a formulation selected from tablet, capsule, dried syrup and liquid. The process for preparing the orally administrable anti-malarial combined preparation comprises the steps of: formulating artemisinine or its derivatives with the pharmaceutically acceptable carrier; and adding pyronaridine or its salt into the formulation.

© KIPO 2006


(KO) 본 발명은 약제학적으로 허용되는 담체와 함께, 유효성분으로서 알테미시닌(artemisinine) 또는 그의 유도체 및 피로나리딘(pyronaridine) 또는 그의 염을 포함하는, 경구투여용 항말라리아 제제에 관한 것이다.
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