(EN) PURPOSE: An orally administrable anti-malarial combined preparation and a preparation process thereof are provided to improve drug stability of the preparation, improve medicine effect of drugs, and inhibit proliferation of drug-resistant bacteria causing malaria.
CONSTITUTION: The orally administrable anti-malarial combined preparation comprises artemisinine or its derivatives and pyronaridine or its salt, and a pharmaceutically acceptable carrier, wherein the weight ratio of the artemisinine or its derivatives, and pyronaridine or its salt is 1:1 to 1:6. The pharmaceutically acceptable carrier is polyethylene glycol, hydroxypropyl methylcellulose, methylcellulose or ethylcellulose, and the preparation has a formulation selected from tablet, capsule, dried syrup and liquid. The process for preparing the orally administrable anti-malarial combined preparation comprises the steps of: formulating artemisinine or its derivatives with the pharmaceutically acceptable carrier; and adding pyronaridine or its salt into the formulation.
© KIPO 2006
(KO) 본 발명은 약제학적으로 허용되는 담체와 함께, 유효성분으로서 알테미시닌(artemisinine) 또는 그의 유도체 및 피로나리딘(pyronaridine) 또는 그의 염을 포함하는, 경구투여용 항말라리아 제제에 관한 것이다.
