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1. (KR1020080113268) ANTI-IGF-IR ANTIBODIES AND USES THEREOF

Office : Republic of Korea
Application Number: 1020087026393 Application Date: 28.10.2008
Publication Number: 1020080113268 Publication Date: 29.12.2008
Publication Kind : A
IPC:
C07K 16/00
A61K 39/395
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
CPC:
C07K 16/2863
A61K2039/505
C07K2317/21
C07K2317/24
C07K2317/33
C07K2317/34
C07K2317/41
C07K2317/52
C07K2317/524
C07K2317/53
C07K2317/55
C07K2317/73
C07K2317/76
C07K2317/77
C07K2317/92
C07K2319/00
Applicants: BIOGEN IDEC MA INC.
Inventors: HARIHARAN KANDASAMY
GRAFF CHRISTILYN
GLASER SCOTT
GARBER ELLEN
REYES CHRISTOPHER L.
DEMAREST STEPHEN
Priority Data: 2006 786347 28.03.2006 US
2006 876554 28.03.2006 US
Title: (EN) ANTI-IGF-IR ANTIBODIES AND USES THEREOF
Abstract: front page image
(EN) The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-IR) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-lR-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-I) and insulin like growth factor 2 (IGF-2) to bind to IGF-IR, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention. ┬ęKIPO&WIPO 2009
Also published as:
NO20084521NZ571964UAa200812599MXMX/a/2008/012146SG146164EP1999149
JP2009532027IL194266CN101415728CA2646406EA200802061AU2007245164
ID049.0429IN8061/DELNP/2008WO/2007/126876