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1. KR1020070116642 - PIPERIDINYL SUBSTITUTED CYCLOHEXANE-1,4-DIAMINES

Office Republic of Korea
Application Number 1020077024214
Application Date 22.10.2007
Publication Number 1020070116642
Publication Date 10.12.2007
Publication Kind A
IPC
C07D 211/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
26with hydrocarbon radicals, substituted by nitrogen atoms
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/445
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
CPC
C07D 211/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
10with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
14with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
C07D 211/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants JANSSEN PHARMACEUTICA N.V.
얀센 파마슈티카 엔.브이.
Inventors CHIU GEORGE
치우 조지
LI SHENGJIAN
리 쉥지안
CONNOLLY PETER J.
콘놀리 피터 제이.
PULITO VIRGINIA L.
푸리토 버지니아 엘.
LIU JINGCHUN
리우 징춘
MIDDLETON STEVEN A.
미들턴 스티븐 에이.
Agents 이은선
최규팔
Priority Data 60/664,302 22.03.2005 US
Title
(EN) PIPERIDINYL SUBSTITUTED CYCLOHEXANE-1,4-DIAMINES
(KO) 피페리디닐 치환 사이클로헥산-1,4-디아민
Abstract
(EN)
The present invention relates to piperidine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as a1a/a1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as method of treatments. ©KIPO&WIPO 2008

(KO)
본 발명은 양성 전립선비대 및 하부 요로 증상의 치료를 위한 α/α 아드레날린수용체 조정자로서 화학식 (I)의 피페리딘 치환 사이클로헥산-1,4-디아민 화합물 및 그의 약제학적으로 허용가능한 형태에 관한 것이다. 본 발명은 또한, 상기 신규한 화합물을 포함하는 약제학적 조성물, 이들 신규한 화합물을 제조하는 신규한 방법 및 의약으로서의 신규한 용도 및 치료 방법에 관한 것이다. 1a 1d