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1. KR1020010108073 - 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY

Office
Republic of Korea
Application Number 1020017008596
Application Date 06.07.2001
Publication Number 1020010108073
Publication Date 07.12.2001
Grant Number 1006159140000
Grant Date 28.08.2006
Publication Kind B1
IPC
C07D 265/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
041,3-Oxazines; Hydrogenated 1,3-oxazines
12condensed with carbocyclic rings or ring systems
14condensed with one six-membered ring
24with hetero atoms directly attached in positions 2 and 4
Applicants ALIZYME THERAPEUTICS LIMITED
알리자임 테라퓨틱스 리미티드
Inventors HODSON HAROLD FRANCIS
호드슨해롤드프란시스
DOWNHAM ROBERT
도운햄로버트
MITCHELL TIMOTHY JOHN
미첼티모씨죤
CARR BEVERLEY JANE
카베버리제인
DUNK CHRISTOPHER ROBERT
던크크리스토퍼로버트
PALMER RICHARD MICHAEL JOHN
팔머리차드마이클죤
Agents 김태홍
김성기
김진회
Priority Data 9900416.0 08.01.1999 GB
Title
(EN) 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY
(KO) 비만 치료용 2-아미노-4Η-3,1-벤족사진-4-온 유도체
Abstract
(EN)

The use of a compound comprising formula (I) or a salt, ester, amide or prodrug therof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality, e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is a 6-membered aromatic or heteroaromatic ring; and R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups.

© KIPO & WIPO 2007


(KO) 본 발명은 바람직한 작용 방식이 에스테르 작용기의 가수분해를 촉매하는 것인 효소의 억제, 예를 들면 제품 및 과정에서 원하지 않은 효소의 제어 및 억제에 있어 하기 화학식(I)을 포함하는 화합물 또는 이것의 약학적으로 허용 가능한 염, 에스테르, 아미드 또는 프로드러그의 용도를 제공한다. 또한, 상기 화합물은 의약 치료, 예를 들면 비만 또는 비만 관련 증상의 치료에 유용하다. 또한, 본 발명은 화학식(I) 내에 속하는 신규한 화합물, 이것의 제조 방법, 이것을 함유하는 약학 조성물 및 이 약학 조성물의 제조 방법에 관한 것이다.
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