KR1020210118812 시클린-의존성 키나제 7 (CDK7)의 억제제

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Republic of Korea

Application Number 1020217016508

Application Date 01.11.2019

Publication Number 1020210118812

Publication Date 01.10.2021

Publication Kind A

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CPC

Applicants 사이로스 파마수티컬스, 인크.

Inventors 마리노, 제이슨, 제이.
추아쿠이, 클라우디오
브래들리, 마이클
시블라, 스테판
카브로, 안젤리카

Agents 양영준
김영

Priority Data 62/754,398 01.11.2018 US
62/877,189 22.07.2019 US
62/915,983 16.10.2019 US
62/927,469 29.10.2019 US

Title

(KO) 시클린-의존성 키나제 7 (CDK7)의 억제제

Abstract

(KO) 본 발명은 화학식 (I) 또는 (Ia)의 화합물, 또는 그의 종, 및 그의 제약상 허용되는 염, 용매화물 (예를 들어, 수화물), 입체이성질체, 호변이성질체, 동위원소 및 다른 특정된 형태를 포함한, 다양한 조성물을 제공한다. 또한, 대상체에서 질환 (예를 들어, 증식성 질환 예컨대 암)을 치료 또는 예방하기 위해 상기 화합물 또는 상기 화합물을 함유하는 제약상 허용되는 조성물을 수반하는 방법 (또는 용도) 및 키트가 제공된다. 본원에 기재된 화합물 또는 제약 조성물의 투여는 시클린-의존성 키나제 7 (CDK7)을 억제하며, 그에 의해, 대상체에서의 종양 세포에서 아폽토시스를 유도할 것으로 예상된다.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9	Compounds containing elements of Groups 5 or 15 of the Periodic System
02	Phosphorus compounds
547	Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558	containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
66	Phosphorus compounds
675	having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9	Compounds containing elements of Groups 5 or 15 of the Periodic System
02	Phosphorus compounds
547	Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558	containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
66	Phosphorus compounds
675	having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

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1. KR1020210118812 - 시클린-의존성 키나제 7 (CDK7)의 억제제

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9	Compounds containing elements of Groups 5 or 15 of the Periodic System
02	Phosphorus compounds
547	Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558	containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
65583	each of the hetero rings containing nitrogen as ring hetero atom