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1. KR1020010071150 - CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF

Office
Republic of Korea
Application Number 1020007011396
Application Date 13.10.2000
Publication Number 1020010071150
Publication Date 28.07.2001
Grant Number 1005082890000
Grant Date 17.08.2005
Publication Kind B1
IPC
C12N 5/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants MICROMET AG
에리히 펠베르마이크로메트 에이지
Inventors DOERKEN BERND
되르켄베른트
RIETHMUELLER GERT
리이트뮐러게르트
KUFER PETER
쿠퍼페터
LUTTERBUSE RALF
룻터뷔세랄프
BARGOU RALF
바르고우랄프
LOEFFLER ANJA
뢰프플러안야
Agents 김명신
Priority Data 98107269.7 21.04.1998 EP
Title
(EN) CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF
(KO) CD19×CD3 특이 폴리펩티드 및 그의 용도
Abstract
(EN)

Described are novel single-chain multifunctional polypeptides comprising at least two binding sites specific for the CD19 and CD3 antigen, respectively. Further provided are polypeptides, wherein the above- described polypeptide comprises at least one further domain, preferably of pre-determined function. Furthermore, polynucleotides encoding said polypeptides as well as to vectors comprising said polynucleotides and host cells transformed therewith and their use in the production of said polypeptides are described, In addition, compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the afore-described polypeptides, polynucleotides or vectors. Described is also the use of the afore-mentioned polypeptides, polynucleotides and vectors for the preparation of pharmaceutical compositions for immunotherapy, preferably against B-cell malignancies such as non-Hodgkin lymphoma.

© KIPO & WIPO 2007


(KO) 본 발명은 CD19 및 CD3 항원 각각에 대해 특이적인 적어도 2개의 결합 부위를 포함하는 단쇄 다기능 폴리펩티드에 관한 것으로서,
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