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1. KR1020200135299 - 카나비노이드의 아세틸화 방법

Office
Republic of Korea
Application Number 1020207022387
Application Date 20.09.2019
Publication Number 1020200135299
Publication Date 02.12.2020
Grant Number 102271508
Grant Date 02.07.2021
Publication Kind B1
IPC
C07D 311/86
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
84with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
86Oxygen atoms, e.g. xanthones
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
C07D 311/86
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
84with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
86Oxygen atoms, e.g. xanthones
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants 넥스트리프 솔루션스 엘티디
Inventors 팔, 크루팔 디벤드라
코, 리안 델모랄
휴스, 브록 애스톤
카셀만, 이반 제이슨
Agents 특허법인 무한
Priority Data 16415782 17.05.2019 US
Title
(KO) 카나비노이드의 아세틸화 방법
Abstract
(KO) 증류, 염석 보조 액체-액체 추출(SALLE), 및 용매 회수 기술을 연속 사용하는 THC-O-아세테이트의 제조방법. 카나비스 오일에서 테트라하이드로카나비놀(THC)은 환류 하에서 아세트산 무수물과 반응하여 THC-O-아세테이트 및 아세트산을 생산한다. 수득된 조 생성물을 증류하고, 다시 증류하기 전에 헥산과 SALLE을 수행한 후, 석유 에테르와 SALLE를 수행하여, 정제된, THC-O-아세테이트 생성물을 수득한다.