1. KR1020010032319 - ?-HYDROXY, -AMINO, AND HALO DERIVATIVES OF ?-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS

The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R1is C4-12alkyl, C4-12alkenyl, C4-12alkynyl, - (CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted-(CH 2)h-het, R2is substituted and unsubstituted C1-12alkyl, substituted and unsubstituted C2-12alkenyl, substituted and unsubstituted C2-12alkynyl, substituted and unsubstituted-(CH2)h-C3-8cycloakyl, substituted and unsubstituted -(CH2)h-C3-8 cycloalkenyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH 2)h- heterocyclic ring, substituted and unsubstituted -(CH2)i-X-R4(X is -O-, -S(=O)j-, -NR7-, -S(=O)2 NR8-, or -C(=O)-), and -(CH2)iCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.

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