Processing

Please wait...

Settings

Settings

Goto Application

1. KR1020190141145 - 피리미딘일-피리딜옥시-나프틸 화합물 및 IRE1-관련 질환 및 장애 치료 방법

Office Republic of Korea
Application Number 1020197030386
Application Date 16.03.2018
Publication Number 1020190141145
Publication Date 23.12.2019
Publication Kind A
IPC
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/506
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/506
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants 제넨테크, 인크.
Inventors 브라운 마리-가브리엘
기본스 폴
리 웬디
라이 추옹
루돌프 요아킴
슈워쯔 자콥
애쉬크나지 애비
푸 레오
라이 타미
왕 페이
베버릿지, 램세이
자오 리앙
Agents 강명구
Priority Data PCT/CN2017/077059 17.03.2017 CN
Title
(KO) 피리미딘일-피리딜옥시-나프틸 화합물 및 IRE1-관련 질환 및 장애 치료 방법
Abstract
(KO)
본 명세서에는 본 명세서에 기재된 치환체 및 구조 특징을 갖고, 하기 화학식 (I) 또는 (I') 구조를 갖는, 이노시톨 요구 효소 1(IRE1) 조절 활성도 또는 기능을 가진 피리미딘일-피리딜옥시-나프틸 화합물, 또는 이의 입체이성질체, 호변이성질체 또는 약제학적으로 허용 가능한 염이 기재된다: . 또한 화학식 (I) 또는 (I') 화합물을 포함하는 약제학적 조성물 및 의약뿐만 아니라, 에스트로겐 수용체에 의존하거나 매개되는 질환 또는 병태를 치료하기 위하여, 이러한 IRE1 조절제를 단독으로 또는 다른 치료제와 병용하여 사용하는 방법이 기재된다. JPEG pct01072.jpg 37 57