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1. (KR1020010012131) PROCESS FOR PRODUCING KETOPROFEN AND 5-BENZOYL-3-METHYL-2-INDOLINONE

Office : Republic of Korea
Application Number: 1019997009963 Application Date: 27.10.1999
Publication Number: 1020010012131 Publication Date: 15.02.2001
Publication Kind : A
IPC:
C07C 59/84
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40
Unsaturated compounds
76
containing keto groups
84
containing six-membered aromatic rings
CPC:
C07D 209/34
Applicants: MEDICAL INFORMATION SERVICES, INC.
가부시키가이샤 이가쿠죠호서비스
Inventors: KONDO HISAO
곤도히사오
HIGASHIKAWA TETSURO
히가시카와데츠로
KUBO AKINARI
구보아키나리
SAITO NAOKI
사이토나오키
Agents: 장용식
Priority Data: 97-111236 28.04.1997 JP
97-209278 04.08.1997 JP
Title: (EN) PROCESS FOR PRODUCING KETOPROFEN AND 5-BENZOYL-3-METHYL-2-INDOLINONE
(KO) 케토프로펜 및 5-벤조일-3-메틸-2-인돌리논의 제조방법
Abstract: front page image
(EN)

A process for producing ketoprofen by benzoylating 3-methyl-2-indolinone with a benzoyl halide, cleaving the amido bond forming the five-membered ring moiety of the formed 5-benzoyl-3-methyl-2-indolinone with a basic compound and replacing an aromatic amino group of the formed compound with a hydrogen atom. A very high yield of ketoprofen can be obtained through ordinary steps, which are short as a whole, without using chemicals of an extremely high toxicity such as cyanides or chemicals of a low handleability, such as liquid ammonia.

© KIPO & WIPO 2007


(KO) 3-메틸-2-인돌리논을 벤조일할라이드로 벤조일화하고, 생성된 5-벤조일-3-메틸-2-인돌리논의 5원 고리부를 형성하고 있는 아미드 결합을 염기성 화합물로 개열시키고, 생성된 화합물의 방향족 아미노기를 수소원자로 치환하는 케토프로펜의 제조방법으로서, 청산화합물 등의 독성이 극히 강한 약품 또는 액체 암모늄 등의 취급성이 나쁜 약품을 사용하지 않는 일반적인 공정으로, 동시에, 전체로서 짧은 공정으로 매우 수율 좋게 케토프로펜을 얻을 수 있다.
Also published as:
EP0990637JP3347745CN1253543CA2288125WO/1998/049127