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1. KR1020180081595 - 이소성 지방 축적의 치료에 사용하기 위한 A3 아데노신 수용체 리간드

Office
Republic of Korea
Application Number 1020187016840
Application Date 22.11.2016
Publication Number 1020180081595
Publication Date 16.07.2018
Grant Number 102103657
Grant Date 23.04.2020
Publication Kind B1
IPC
A61K 31/7076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
CPC
A61K 31/7076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants 캔-파이트 바이오파마 리미티드
Inventors 피쉬맨, 프니나
코헨, 시라
Agents 허용록
Priority Data 242723 23.11.2015 IL
Title
(KO) 이소성 지방 축적의 치료에 사용하기 위한 A3 아데노신 수용체 리간드
Abstract
(KO) 본 발명은 특히 지방 간에서 이소성 지방 축적을 감소시키기 위한 AAR 리간드에 관한 것이다. 또한, 본 발명은 이러한 지방 축적 감소용 약학 조성물의 제조를 위한 AAR 리간드의 용도, 상기 리간드를 이용한 지방 축적과 관련된 질병의 치료 방법, 및 이소성 지방 축적과 관련된 질병을 치료하기 위한 AAR 리간드를 포함하는 약학 조성물 및 이의 사용 설명서를 포함하는 키트를 제공한다. 일 실시예에서, 본 발명은 지방 간, 특히 비-알콜성 지방간 질환 (NAFLD)을 치료하기 위한, AAR 작용제, 예를 들어 2-클로로-N-(3-아이오도벤질)-아데노신-5'-N-메틸우론아미드 (Cl-IB-MECA, CF102)의 용도를 제공한다. 3 3 3 3 6
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