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1. KR1020180029971 - ROR 감마 조절제로서의 치환된 테트라하이드로퀴놀리논 화합물

Office
Republic of Korea
Application Number 1020177036129
Application Date 13.05.2016
Publication Number 1020180029971
Publication Date 21.03.2018
Publication Kind A
IPC
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61K 31/4725
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
Applicants 오리진 디스커버리 테크놀로지스 리미티드
Inventors 코트라바사이아 우찌나마타다 라비
판디트 체탄
Agents 손민
Priority Data 2448/CHE/2015 15.05.2015 IN
Title
(KO) ROR 감마 조절제로서의 치환된 테트라하이드로퀴놀리논 화합물
Abstract
(KO) 본 발명은 레티노산 수용체 관련 희귀 수용체 (ROR)의 조절제로서, 특히 RORγ 조절제로서 치료학적으로 유용한, 화학식 (I)의 치환된 테트라하이드로퀴놀리논 및 관련 화합물을 제공한다. 이러한 화합물은 질환 및/또는 장애, 특히 RORγ 수용체에 의해 매개된 질환 및/또는 장애의 치료 및 예방에 사용하기에 유용하다. 본 발명은 또한 상기 화합물 및 적어도 하나의 화학식 (I)의 치환된 테트라하이드로퀴놀리논 또는 관련 화합물과 함께 약학적으로 용인되는 담체, 희석제 또는 부형제를 포함하는 약학 조성물의 제조를 제공한다.
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