KR1020180029971 ROR 감마 조절제로서의 치환된 테트라하이드로퀴놀리논 화합물

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Republic of Korea

Application Number 1020177036129

Application Date 13.05.2016

Publication Number 1020180029971

Publication Date 21.03.2018

Publication Kind A

IPC

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Applicants 오리진 디스커버리 테크놀로지스 리미티드

Inventors 코트라바사이아 우찌나마타다 라비
판디트 체탄

Agents 손민

Priority Data 2448/CHE/2015 15.05.2015 IN

Title

(KO) ROR 감마 조절제로서의 치환된 테트라하이드로퀴놀리논 화합물

Abstract

(KO) 본 발명은 레티노산 수용체 관련 희귀 수용체 (ROR)의 조절제로서, 특히 RORγ 조절제로서 치료학적으로 유용한, 화학식 (I)의 치환된 테트라하이드로퀴놀리논 및 관련 화합물을 제공한다. 이러한 화합물은 질환 및/또는 장애, 특히 RORγ 수용체에 의해 매개된 질환 및/또는 장애의 치료 및 예방에 사용하기에 유용하다. 본 발명은 또한 상기 화합물 및 적어도 하나의 화학식 (I)의 치환된 테트라하이드로퀴놀리논 또는 관련 화합물과 함께 약학적으로 용인되는 담체, 희석제 또는 부형제를 포함하는 약학 조성물의 제조를 제공한다.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02	containing two hetero rings
04	directly linked by a ring-member-to-ring- member bond

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
47	Quinolines; Isoquinolines
472	Non-condensed isoquinolines, e.g. papaverine
4725	containing further heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29	Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37	Drugs for immunological or allergic disorders

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14	containing three or more hetero rings

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1. KR1020180029971 - ROR 감마 조절제로서의 치환된 테트라하이드로퀴놀리논 화합물