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1. KR1020170123658 - 장 수용체를 활성화시키는 파네소이드 X 수용체 작용제를 사용한 성인 잠복성 자가면역 당뇨병의 치료

Office Republic of Korea
Application Number 1020177027280
Application Date 11.03.2016
Publication Number 1020170123658
Publication Date 08.11.2017
Publication Kind A
IPC
A61K 31/216
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
216of acids having aromatic rings, e.g. benactizyne, clofibrate
A61K 31/416
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
416condensed with carbocyclic ring systems, e.g. indazole
A61K 31/422
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
422not condensed and containing further heterocyclic rings
A61K 31/427
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
427not condensed and containing further heterocyclic rings
A61K 31/439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
439the ring forming part of a bridged ring system, e.g. quinuclidine
A61K 31/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
Applicants 더 솔크 인스티튜트 포 바이올로지칼 스터디즈
Inventors 황, 성순
요시하라, 에이지
유, 루스, 티.
앳킨스, 아네트
다운즈, 마이클
에반스, 로날드, 엠.
Agents 이원희
Priority Data 62/133,042 13.03.2015 US
Title
(KO) 장 수용체를 활성화시키는 파네소이드 X 수용체 작용제를 사용한 성인 잠복성 자가면역 당뇨병의 치료
Abstract
(KO)
피험자에서 성인 잠복성 자가면역 당뇨병(latent autoimmune diabetes of adults, LADA)의 치료 또는 예방 방법의 일실시예들이 개시되어있다. 몇몇 일실시예들은 하나 또는 그 이상의 파네소이드 X 수용체 (FXR) 작용제 화합물을 약학적 유효량만큼 위장관을 통해 피험자에게 투여하여, 장 내 FXR 수용체를 활성화시킴으로서, 피험자의 성인 잠복성 자가면역 당뇨병을 치료 또는 예방하는 것을 포함한다.