KR1020170007480 약제학적 제형에 사용하기 위한 PI3K 델타 선택적 억제제의 개선된 형태

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Republic of Korea

Application Number 1020167036318

Application Date 26.05.2015

Publication Number 1020170007480

Publication Date 18.01.2017

Publication Kind A

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Applicants 리젠 파마슈티컬스 소시에떼 아노님

Inventors 박칼란카, 스와루프 쿠마르 벤카타 사티야

Agents 김순웅

Priority Data 2596/CHE/2014 27.05.2014 IN
2597/CHE/2014 27.05.2014 IN

Title

(KO) 약제학적 제형에 사용하기 위한 PI3K 델타 선택적 억제제의 개선된 형태

Abstract

(KO) 본 발명은 선택적인 PI3K 델타 억제제 (S)-2-(1-(4-아미노-3-(3-플루오로-4-아이소프로폭시페닐)-1H-피라졸로[3,4-d]피리미딘-1-일)에틸)-3-(3-플루오로페닐)-4H-크로멘-4-온(TGR-1202)의 p-톨루엔설폰산 염(PTSA)의 고체상 형태에 관한 것이다. 본 발명은 또한 이의 제조 방법, 이를 함유하는 약제학적 조성물, 및 이를 투여하여, PI3K 키나제 매개 질환 또는 장애, 예컨대 암을 치료하는 방법에 관한 것이다.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
487	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
335	having oxygen as the only ring hetero atom, e.g. fungichromin
35	having six-membered rings with one oxygen as the only ring hetero atom
352	condensed with carbocyclic rings, e.g. cannabinols, methantheline

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
487	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
335	having oxygen as the only ring hetero atom, e.g. fungichromin
35	having six-membered rings with one oxygen as the only ring hetero atom
352	condensed with carbocyclic rings, e.g. cannabinols, methantheline

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1. KR1020170007480 - 약제학적 제형에 사용하기 위한 PI3K 델타 선택적 억제제의 개선된 형태

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
B	GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200	Indexing scheme relating to specific properties of organic compounds
13	Crystalline forms, e.g. polymorphs

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
309	Sulfonic acids; Halides, esters, or anhydrides thereof
01	Sulfonic acids
28	having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
29	of non-condensed six-membered aromatic rings
30	of six-membered aromatic rings substituted by alkyl groups