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1. KR1020140060290 - mRNA 의 poly(A) 사슬 및/또는 3'' 말단 배열의 일부를 절단하여 번역 반응을 억제하는 기술

Office
Republic of Korea
Application Number 1020147003977
Application Date 17.07.2012
Publication Number 1020140060290
Publication Date 19.05.2014
Publication Kind A
IPC
C12N 15/09
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
111General methods applicable to biologically active non-coding nucleic acids
A01K 67/027
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01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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027New breeds of vertebrates
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2207Modified animals
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01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
40Fish
A01K2267/03
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Applicants 고리츠다이가쿠호진 요코하마시리츠다이가쿠
가부시키가이샤 요신도
고쿠리츠다이가쿠호진 토쿄고교 다이가꾸
Inventors 와다 다다시
다케다 게이
한다 히로시
Agents 특허법인코리아나
Priority Data JP-P-2011-160512 22.07.2011 JP
Title
(KO) mRNA 의 poly(A) 사슬 및/또는 3'' 말단 배열의 일부를 절단하여 번역 반응을 억제하는 기술
Abstract
(KO)
종래법 (RNAi 법·리보자임법·안티센스법) 보다 설계가 간편하며 또한 효과의 확인도 용이한 인위적 유전자 발현 억제 방법을 제공한다. 표적 mRNA 의 poly(A) 사슬 및/또는 3' 말단 배열의 일부를 절단하는 것을 포함하는, 표적 유전자의 번역 반응을 억제하는 방법. 표적 mRNA 의 poly(A) 사슬 및/또는 3' 말단 배열의 일부를 절단할 수 있는 시약을 함유하는, 번역 반응을 억제하기 위한 키트 ; 표적 mRNA 의 poly(A) 사슬 및/또는 3' 말단 배열의 일부를 절단할 수 있는 시약이 도입되어, 표적 유전자의 번역 반응이 억제된 세포 ; 및 표적 mRNA 의 poly(A) 사슬 및/또는 3' 말단 배열의 일부를 절단할 수 있는 시약이 도입되어, 표적 유전자의 번역 반응이 억제된 비인간 생물도 제공된다.