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1. KR1020120135419 - 치료학적 DLL4 결합 단백질

Office Republic of Korea
Application Number 1020127025770
Application Date 28.02.2011
Publication Number 1020120135419
Publication Date 13.12.2012
Grant Number 1018532780000
Grant Date 02.05.2018
Publication Kind B1
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
C07K 16/18
A61K 39/395
A61P 35/00
C12N 15/13
CPC
C07K 16/18
A61K 39/395
C07K 16/22
C07K 16/24
C07K 16/28
C07K 14/435
Applicants 아비에 인코포레이티드
애브비 인코포레이티드
Inventors 리 잉춘
구 지지에 제임스
모르간-라페 수잔
천 밍쥬
시에 충-밍
리 잉춘
구 지지에 제임스
모르간-라페 수잔
천 밍쥬
시에 충-밍
Agents 장훈
장훈
Priority Data 61/309,494 02.03.2010 US
Title
(KO) 치료학적 DLL4 결합 단백질
Abstract
(KO)
항체, CDR-이식된 항체, 사람화된 항체, 및 이의 DLL4 결합 단편, 고 친화성으로 DLL4에 결합하는 단백질, 및 DLL4 및/또는 VEGF 활성을 중화하는 DLL4 결합 단백질을 포함하는 DLL4 결합 단백질이 본원에 기술되어 있다. DLL4 결합 단백질은 암 및 종양을 치료하거나 예방하고, 특히 종양 혈관형성을 치료하거나 예방하는데 유용하다.