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1. (KR1020120062839) 단백질 키나제 억제제로서의 화합물 및 조성물

Office : Republic of Korea
Application Number: 1020127007860 Application Date: 27.08.2010
Publication Number: 1020120062839 Publication Date: 14.06.2012
Grant Number: 1014133920000 Grant Date: 27.06.2014
Publication Kind : B1
Prior PCT appl.: Application Number:PCTUS2010046930 ; Publication Number:WO2011025927 Click to see the data
IPC:
C07D 403/04
C07D 401/14
A61K 31/506
A61P 35/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: 노파르티스 아게
아이알엠 엘엘씨
Inventors: 후앙, 센린
진, 시안밍
리우, 주오셍
푼, 다니엘
텔류, 존 이.
완, 용친
왕, 싱
시에, 용핑
Agents: 위혜숙
양영준
Priority Data: 61/238,073 28.08.2009 US
61/313,039 11.03.2010 US
Title: (KO) 단백질 키나제 억제제로서의 화합물 및 조성물
Abstract:
(KO) 본 발명은 신규 부류의 하기 화학식 I의 화합물, 상기 화합물을 포함하는 제약 조성물, 및 비정상적이거나 탈조절된 키나제 활성과 관련된 질환 또는 장애, 특히 B-Raf의 비정상적 활성화를 수반하는 질환 또는 장애를 치료하거나 예방하기 위한 상기 화합물의 사용 방법을 제공한다. <화학식 I> TIFF 112012024375536-pct00086.tif 45 63
Also published as:
RSP-2014/0430UAa201203042SG178351IL218084EP2470526DOP2012000051
JP2013503186CN102725283CA2771775EA201200373EP2727918ES2492499
TN2012000081NZ598924DK2470526AU2010286569VN30470ID2012/03594
TH140028IN2469/DELNP/2012WO/2011/025927