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1. KR1020110097839 - 항-cMet 항체

Office
Republic of Korea
Application Number 1020117013758
Application Date 02.12.2009
Publication Number 1020110097839
Publication Date 31.08.2011
Grant Number 1018382990000
Grant Date 14.03.2018
Publication Kind B1
IPC
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 15/13
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
CPC
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
Applicants 피에르 파브르 메디카먼트
피에르 파브르 메디카먼트
Inventors 고뜨쉬, 릴리앙
위르쉬, 띠에리
고뜨쉬, 릴리앙
베, 쎄드리끄
위르쉬, 띠에리
베, 쎄드리끄
Agents 한인열
한인열
Priority Data PCT/IB2008/055663 02.12.2008 IB
61/184,502 05.06.2009 US
Title
(KO) 항-cMet 항체
Abstract
(KO) 인간 c-Met 수용체에 특이적으로 결합할 수 있는 및/또는 상기 수용체의 타이로신 키나제 (tyrosine kinase) 활성을 특이적으로 저해할 수 있는 개선된 길항 활성 (antagonistic activity)을 가지는 항체이고, 상기 항체는 변형된 힌지 (modified hinge) 부위를 포함한다. 이러한 c-Met에 대한 항체 길항제를 포함하는 조성물 및 그의 암을 치료하는 약물로서의 용도이다.
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