KR1020110021901 골수증식성 질환 및 혈전성 질환의 치료를 위한 아나그렐리드 유사체로서 이미다조퀴나졸린 유도체

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Republic of Korea

Application Number 1020107028382

Application Date 13.05.2009

Publication Number 1020110021901

Publication Date 04.03.2011

Publication Kind A

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CPC

Applicants 샤이어 엘엘씨

Inventors 골링 버나드
프랭클린 리차드
맥클레오드 앵거스

Agents 김진회
강승옥

Priority Data 0808944.3 16.05.2008 GB

Title

(KO) 골수증식성 질환 및 혈전성 질환의 치료를 위한 아나그렐리드 유사체로서 이미다조퀴나졸린 유도체

Abstract

(KO) 본 발명은 심혈관 부작용에 대한 감소된 잠재성을 가지며 환자의 수용상태가 개선되며 골수증식성 질환의 치료가 안전한 선택된 혈소판 강하제인 아나그레라이드의 치환된 유사체의 발견에 관한 것이다. 더욱 상세하게는, 본 발명은 치환기가 청구항 1에서 정의된 바와 같은 의미를 갖는 하기의 일반식을 가지며 인간의 혈소판 강하제로서 유용성을 갖는 임의의 아미다조퀴나졸린 유도체에 관한 것이다: 본 발명의 화합물은 거대핵세포형성을 억제하여 혈소판의 형성을 억제하는 기능을 한다. JPEG pct00013.jpg 43 72

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
487	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7	Drugs for disorders of the blood or the extracellular fluid
02	Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
487	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings

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1. KR1020110021901 - 골수증식성 질환 및 혈전성 질환의 치료를 위한 아나그렐리드 유사체로서 이미다조퀴나졸린 유도체