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1. KR1020100098597 - ＨＩＶ 특이적 항체에 기반한 ＨＩＶ 예방 백신

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Republic of Korea
Application Number 1020107009984
Application Date 09.10.2008
Publication Number 1020100098597
Publication Date 08.09.2010
Publication Kind A
IPC
A61K 39/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
CPC
A61K 39/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
C12N2740/16134
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740Reverse Transcribing RNA Viruses
00011Reverse Transcribing RNA Viruses
10011Retroviridae
16011Human Immunodeficiency Virus, HIV
16111concerning HIV env
16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applicants 테크놀러지 인터그럴 엘티디.
Inventors 필리노바 엘리나 위.
Agents 리앤목특허법인
Priority Data 60/978,536 09.10.2007 US
Title
(KO) ＨＩＶ 특이적 항체에 기반한 ＨＩＶ 예방 백신
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Abstract
(KO) 본 발명은 HIV 백신을 제조하는 방법, HIV에 의한 감염을 예방하는 방법, 및/또는 개체에서 HIV 감염의 발생을 예방하는 방법에 관한 것이다. 특히, 본 발명은 개체에서 면역 반응으로서 현재의 역학적 코호트(epidemiologic cohort)에 존재하는 HIV-서브타입 및 항레트로바이러스 치료 후에 선택된 돌연변이체에 결합하는, 실질적으로 모든 HIV-이소형을 인식하고 결합할 수 있는 HIV 특이적 항체의 형성을 제공한다. 본 발명은 또한, 역 패닝(reverse panning) 기법에 의한 HIV-1 펩티드/폴리펩티드/단백질 선택, HIV-1 env 펩티드/폴리펩티드/단백질, 특히, gp120 및 그의 단편의 LC 질량 분광분석법에 의한 확인, 적절한 숙주, 락토바실러스 타렌톨라애(L. tarentolae)에서 필요한 글리코실화를 갖는 재조합 HIV-1 env 펩티드의 생성, 및 HIV-특이적 면역 강화(boost) 조성물을 위한 아쥬반트-담체로서 입체적으로 안정화된 리포좀(sterically stabilized liposome, SSL)의 이용에 관한 것이다.
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