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1. (KR1019990067270) 지질농도를 조절하는 제약 조성물 및 방법

Office : Republic of Korea
Application Number: 1019980703240 Application Date: 01.05.1998
Publication Number: 1019990067270 Publication Date: 16.08.1999
Grant Number: 1004496040000 Grant Date: 16.11.2004
Publication Kind : B1
Prior PCT appl.: Application Number:PCTUS1996015854 ; Publication Number:WO199716184 Click to see the data
IPC:
A61K 31/215
A61K 31/41
A61K 31/44
A61K 31/40
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Applicants: 로즈 암스트롱, 크리스틴 에이. 트러트웨인워너-램버트 캄파니
Inventors: 보칸, 토마스, 엠., 에이.
Agents: 김영
위혜숙
Priority Data: 60/006.155 02.11.1995 US
Title: (KO) 지질농도를 조절하는 제약 조성물 및 방법
Abstract:
(KO) 본 발명은 지질 조절에 효과적인, 예를 들면, 술팜산, [[2,4,6-트리스(1-메틸에틸)-페닐]아세틸]-, 2,6-비스[(1-메틸에틸)페닐 에스테르와 같은 ACAT 억제제, 및 예를 들면, 아토르바스타틴과 같은 HMG-CoA 환원효소 억제제의 조합에 관한 것이다. 이러한 시약의 조합은 혈장 VLDL 및 LDL 콜레스테롤을 크게 감소시키며 어느 한 쪽 단독으로보다 HDL 콜레스테롤을 증가시켜서 아테롬 발생성 지단백질 특성을 적게 한다. 이 조합은 허혈성 증후군이 발병하거나 또는 발병의 위험이 있는 환자의 치료에서 내생적 혈관 내피 의존 활성을 회복하기 위해서 유용하다.
Also published as:
CZPV1998-1271IS4720NO19981961SK55798KR1020040029459SG53241
IL123902EP0858336US6124309JPH11515025 CN1201389CN1679953
CA2233558EA199800420NZ319906NZ512484AU1996072539IN2115/DEL/1996
GEP20001898BWO/1997/016184