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1. (JP2012193211) COMPOSITION FOR PREVENTING CARDIOVASCULAR EVENT DEVELOPMENT

Office : Japan
Application Number: 2012157914 Application Date: 13.07.2012
Publication Number: 2012193211 Publication Date: 11.10.2012
Grant Number: 5809115 Grant Date: 10.11.2015
Publication Kind : B2
IPC:
A61K 31/22
A61K 31/232
A61K 45/00
A61P 9/10
A61P 43/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
23
of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232
having three or more double bonds, e.g. etretinate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants: 持田製薬株式会社
Inventors: 横山 光宏
折笠 秀樹
松▲崎▼ 益▲徳▼
松澤 佑次
齋藤 康
石川 雄一
及川 眞一
佐々木 淳
菱田 仁士
板倉 弘重
北 徹
北畠 顯
中谷 矩章
坂田 利家
島田 和幸
白土 邦男
Agents: 渡辺 望稔
三和 晴子
Priority Data: 2005200503 08.07.2005 JP
Title: (EN) COMPOSITION FOR PREVENTING CARDIOVASCULAR EVENT DEVELOPMENT
(JA) 心血管イベント予防用製剤
Abstract:
(EN)

PROBLEM TO BE SOLVED: To provide a composition for preventing development and/or recurrence of a cardiovascular event, useful for preventing the development and/or the recurrence of the cardiovascular event and expected to have a preventive effect on the development and/or the recurrence of, especially, a cardiovascular event which develops and/or recurs in a hyperlipemia patient, although the patient has been treated with an HMG-CoA RI, or more especially, a cardiovascular event which occurs after undergoing a cardiovascular reconstruction operation and then passing through an unstable period.

SOLUTION: The composition for preventing cardiovascular event development contains ethyl icosapentaenoate and a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, and prevents a cardiovascular event development which occurs after an unstable period subsequent to a cardiovascular reconstruction.

COPYRIGHT: (C)2013,JPO&INPIT


(JA)

【課題】心血管イベント発症および/または再発の予防に有用で、特に、高脂血症患者でHMG−CoA RIによる治療を行なったにもかかわらず発症および/または再発する心血管イベント、あるいは特に心血管再建術施行後不安定期を経過した後に起こる心血管イベントの発症および/または再発の予防効果が期待される心血管イベント発症および/または再発予防用組成物の提供。
【解決手段】イコサペント酸エチルエステルと3−ヒドロキシ−3−メチルグルタリルコエンザイムA還元酵素阻害剤とを含有する、心血管再建術施行後不安定期を経過した後に起こる心血管イベントの発症を予防する心血管イベント予防用組成物。
【選択図】なし


Also published as:
NO20065384EP1790339BRPI0613704-0JP2007039452JP2008050367US20070021504
US20130065956CN101217952CN102526733CA2570763ES2489741KR1020130137055
US20160045469WO/2007/007686