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1. (JP2012513433) P2X7モジュレーターとしてのジヒドロピリドンアミド

Office : Japan
Application Number: 2011542760 Application Date: 14.12.2009
Publication Number: 2012513433 Publication Date: 14.06.2012
Publication Kind : A
IPC:
C07D 401/12
A61P 25/04
A61P 29/00
A61K 31/4439
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
Applicants: エフ.ホフマン−ラ ロシュ アーゲー
F. HOFFMANN−LA ROCHE AKTIENGESELLSCHAFT
Inventors: バーガー,ジェイコブ
カルーン,ジョン・マリー
クラウス,ナンシー・エリザベス
ロペス−タピア,フランシスコ・ハビアー
ウォーカー,キース・エイドリアン・マレー
ツァオ,シュ−ハイ
Agents: 津国 肇
齋藤 房幸
Priority Data: 61/203,482 23.12.2008 US
Title: (JA) P2X7モジュレーターとしてのジヒドロピリドンアミド
Abstract:
(JA)

式(I)で示される化合物又は薬学的に許容しうるその塩(式中、m、n、R、R、R、R、R、及びRは本明細書で定義されたとおりである)。その化合物を製造する又はその化合物をP2X7プリン受容体に関連する疾患の処置用に使用する方法もまた開示されている。


Also published as:
AR074843IL213417MXMX/a/2011/006232SG172336EP2385939CN102264723
CA2745864MX2011006232KR1020110086768AU2009331659IN4420/CHENP/2011WO/2010/072597