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1. JP2021169519 - NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS

Office
Japan
Application Number 2021119885
Application Date 20.07.2021
Publication Number 2021169519
Publication Date 28.10.2021
Publication Kind A5
IPC
C07C 323/41
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
23containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
39at least one of the nitrogen atoms being part of any of the groups X being a hetero atom, Y being any atom
40Y being a hydrogen or a carbon atom
41Y being a hydrogen or an acyclic carbon atom
C07D 211/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68having one double bond between ring members or between a ring member and a non-ring member
72with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
74Oxygen atoms
76attached in position 2 or 6
C07D 309/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
309Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
16having one double bond between ring members or between a ring member and a non-ring member
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30Oxygen atoms, e.g. delta-lactones
A61K 31/366
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
A61K 31/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/445
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
CPC
A61K 8/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
46containing sulfur
A61K 8/4926
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4906with one nitrogen as the only hetero atom
4926having six membered rings
A61K 8/498
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4973with oxygen as the only hetero atom
498having 6-membered rings or their condensed derivatives, e.g. coumarin
A61Q 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
C07C 327/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
28having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07C 327/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
30having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Applicants ABREVA AB
アブリバ エービー
Inventors ESKIL ELMER
エスキル エルメル
MAGNUS JOAKIM HANSSON
マグヌス ジョアキム ハンソン
KARL HENRIK JOHANNES EHINGER
カール ヘンリク ジョハンネス エヒンゲル
STEVEN MOSS
スティーブン モス
Agents 石川 徹
Priority Data PA201470190 08.04.2014 DK
Title
(EN) NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS
(JA) 新規な細胞透過性サクシネート化合物
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide novel cell-permeable succinates and cell-permeable precursors of the succinates aimed at increasing ATP production in mitochondria.

SOLUTION: Provided is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, where the dotted bond between A and B denotes an optional bond to form a ring-closed structure; Z is selected from -CH2-CH2- and >CH(CH3); A is selected from -SR, -OR and NHR; and B is selected from -O-R', -NHR'', -SR''' and -OH.

SELECTED DRAWING: None

COPYRIGHT: (C)2022,JPO&INPIT


(JA)

【課題】ミトコンドリアでのATP産生を増加することを目的とする、新規な細胞透過性サクシネート及びサクシネートの細胞透過性前駆体を提供する。
【解決手段】式(I)で表わされる化合物、又はその医薬として許容し得る塩(式中、A-B間の点線の結合は、閉環構造を形成するような任意の結合を示し、Zは、-CH2-CH2-又は>CH(CH3)から選択され、Aは、-SR、-OR、及びNHRから選択され、Bは、-O-R’、-NHR’’、-SR’’’、又は-OHから選択される)を提供する。

【選択図】なし