JP2021169519 NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS

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Application Number 2021119885

Application Date 20.07.2021

Publication Number 2021169519

Publication Date 28.10.2021

Publication Kind A5

IPC

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Applicants ABREVA AB
アブリバ　エービー

Inventors ESKIL ELMER
エスキル　エルメル
MAGNUS JOAKIM HANSSON
マグヌス　ジョアキム　ハンソン
KARL HENRIK JOHANNES EHINGER
カール　ヘンリク　ジョハンネス　エヒンゲル
STEVEN MOSS
スティーブン　モス

Agents 石川　徹

Priority Data PA201470190 08.04.2014 DK

Title

(EN) NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS

(JA) 新規な細胞透過性サクシネート化合物

Abstract

(EN)

PROBLEM TO BE SOLVED: To provide novel cell-permeable succinates and cell-permeable precursors of the succinates aimed at increasing ATP production in mitochondria.

SOLUTION: Provided is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, where the dotted bond between A and B denotes an optional bond to form a ring-closed structure; Z is selected from -CH₂-CH₂- and >CH(CH₃); A is selected from -SR, -OR and NHR; and B is selected from -O-R', -NHR'', -SR''' and -OH.

SELECTED DRAWING: None

(JA)

【課題】ミトコンドリアでのATP産生を増加することを目的とする、新規な細胞透過性サクシネート及びサクシネートの細胞透過性前駆体を提供する。
【解決手段】式(I)で表わされる化合物、又はその医薬として許容し得る塩（式中、A-B間の点線の結合は、閉環構造を形成するような任意の結合を示し、Zは、-CH₂-CH₂-又は>CH(CH₃)から選択され、Aは、-SR、-OR、及びNHRから選択され、Bは、-O-R’、-NHR’’、-SR’’’、又は-OHから選択される）を提供する。

【選択図】なし

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
323	Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
23	containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
39	at least one of the nitrogen atoms being part of any of the groups X being a hetero atom, Y being any atom
40	Y being a hydrogen or a carbon atom
41	Y being a hydrogen or an acyclic carbon atom

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
211	Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04	with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68	having one double bond between ring members or between a ring member and a non-ring member
72	with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
74	Oxygen atoms
76	attached in position 2 or 6

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
309	Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
16	having one double bond between ring members or between a ring member and a non-ring member
28	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30	Oxygen atoms, e.g. delta-lactones

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
335	having oxygen as the only ring hetero atom, e.g. fungichromin
365	Lactones
366	having six-membered rings, e.g. delta-lactones

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

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1. JP2021169519 - NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3	Drugs for disorders of the metabolism

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q	SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19	Preparations for care of the skin

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change