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1. JP2021522506 - 質量分析を用いる免疫グロブリンの同定

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Office
Japan
Application Number 2020561661
Application Date 03.05.2019
Publication Number 2021522506
Publication Date 30.08.2021
Publication Kind A
IPC
G01N 27/62
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
62by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
C07K 1/107
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
107by chemical modification of precursor peptides
CPC
G01N 33/57426
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57426leukemia
G01N 33/6851
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6848Methods of protein analysis involving mass spectrometry
6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
G01N 33/6854
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6854Immunoglobulins
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 30/7266
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
62Detectors specially adapted therefor
72Mass spectrometers
7233interfaced to liquid or supercritical fluid chromatograph
724Nebulising, aerosol formation or ionisation
7266by electric field, e.g. electrospray
Applicants ザ　バインディング　サイト　グループ　リミティド
Inventors ダーナンジャイ　サクリカール
スティーブン　ハーディング
デイビッド　バーニッジ
ミシェル　ラジコ
Agents 青木　篤
三橋　真二
渡辺　陽一
中島　勝
武居　良太郎
Priority Data 1808529.0 24.05.2018 GB
62/667,076 04.05.2018 US
Title
(JA) 質量分析を用いる免疫グロブリンの同定
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Abstract
(JA)

本出願は質量分析を用いるイオン化及び検出前の免疫グロブリンの前精製なしに生体試料由来の免疫グロブリンを同定する及び／又は定量化する材料及び方法に関する。例えば単クローン性の免疫グロブリン由来の単クローン性の軽鎖は、酸及び還元剤を含む水性の緩衝液によって単クローン性の免疫グロブリンを含む試料を希釈し、続いてα−シアノ−４−ヒドロキシケイ皮酸マトリックス（ＣＨＣＡ）を有する試料と混合した後に、マトリックス支援レーザー脱離イオン化−飛行時間型（ＭＡＬＤＩ−ＴＯＦ）質量分析を用いて観察されうる。別の例において、無処置の単クローン性の免疫グロブリンは、水によって単クローン性の免疫グロブリンを含む試料を希釈し、続いてＣＨＣＡマトリックスによって試料を混合した後に、ＭＡＬＤＩ−ＴＯＦ質量分析を用いて試料中に観察されうる。
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